Partner John Villafranco and associate Kristi Wolff authored the Nutritional Outlook article, “Caffeine Labeling: An Industry Call to Action.” In April, the Council for Responsible Nutrition (CRN) announced new recommended guidelines for caffeine-containing dietary supplements. This article addresses how caffeine is regulated in food and dietary supplements, recent concerns regarding caffeine content, and CRN’s actions to address the topic. It also provides best-practice considerations for the nutritional supplement industry.